Sam was born to John and Mary Winchester in Lawrence, Kansas. When he was six months old, Balthazar entered his nursery and killed his mother Mary Winchester. John placed Sammy into his brother’s arms and told him to run.
Raised on the road being taken care of mainly by his brother Dean Winchester, they were trained to hunt Vampires, never staying in one place. Sam hated the life they lived and wanted to stay in one school, have friends, live a normal life. Always strong-willed and stubborn like his father John, Sam fought their lifestyle through his teenage years, finally giving up and leaving for college.
Four years later Dean showed up on Sam’s doorstep with news: their dad had gone missing. After following a few leads and finding nothing, Sam went back to Stanford, only to discover that Balthazar had come back into their lives, killing his girlfriend, Jessica. Swearing to hunt the man down, Sam set out again on the hunt with Dean.
Balthazar soon found them. Dean handed his life over to save Sam’s. Determined to save his brother, Sam found himself at Cal Sci University searching for the blueprints to Balthazar’s penthouse, and ran into Charles Eppes who urged him to find Nicolaus Valerius Meridius in New Orleans.
Driving straight from Los Angeles to New Orleans, he barged into the Manor seeking help and refuge.
Nick and Gaius Cassius Longinus agreed to help and returned to Los Angeles to confront Balthazar. In the ensuing battle, Sam was stabbed by Cassie Robinsonand mortally wounded; he consented to be Turned.